65 research outputs found

    Neural indicators of fatigue in chronic diseases : A systematic review of MRI studies

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    The authors would like to thank the Sir Jules Thorn Charitable Trust for their financial support.Peer reviewedPublisher PD

    Age Related Changes in Cerebrovascular Reactivity and Its Relationship to Global Brain Structure

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    ACKNOWLEDGMENTS This study was funded by Alzheimerā€™s Research UK (ARUK) and the Aberdeen Biomedical Imaging Centre, University of Aberdeen. GDW, ADM and CS are part of the SINASPE collaboration (Scottish Imaging Network - A Platform for Scientific Excellence www.SINAPSE.ac.uk). The authors thank Gordon Buchan, Baljit Jagpal, Nichola Crouch, Beverly Maclennan and Katrina Klaasen for their help with running the experiment and Dawn Younie and Teresa Morris for their help with recruitment and scheduling. We also thank the residents of Aberdeen and Aberdeenshire, and further afield, for their generous participation.Peer reviewedPublisher PD

    Cognition and brain iron deposition in whole grey matter regions and hippocampal subfields

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    ACKNOWLEDGEMENTS We are grateful to the Aberdeen Children of the 1950's (ACONF) subset of Generation Scotland GS:SFHS who took part in the STRADL study, supported and funded by the Wellcome Trust Strategic Award ā€˜Stratifying Resilience and Depression Longitudinallyā€™ (STRADL) [104036/Z/14/Z]. Generation Scotland received core support from the Chief Scientist Office of the Scottish Government Health Directorates [CZD/16/6] and the Scottish Funding Council [HR03006] and is currently supported by the Wellcome Trust [216767/Z/19/Z]. HS is supported by the Roland Sutton Academic Trust [0076/R/19]. We also thank the STRADL project team. Research Funding Chief Scientist Office. Grant Number: CZD/16/6 Roland Sutton Academic Trust. Grant Number: 0076/R/19 Scottish Funding Council. Grant Number: HR03006 Wellcome Trust. Grant Number: 104036/Z/14/ZPeer reviewedPublisher PD

    The cerebellum plays more than one role in the dysregulation of appetite : Review of structural evidence from typical and eating disorder populations

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    ACKNOWLEDGMENTS I would like to extend my sincere gratitude to the Northwood Charitable Trust for funding my PhD studentship. Grant Number: RG15207Peer reviewedPublisher PD

    Brainstem volume mediates seasonal variation in depressive symptoms : A cross sectional study in the UK Biobank cohort

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    This research has been conducted using the UK Biobank resource. UK Biobank was established by the Wellcome Trust medical charity, Medical Research Council, Department of Health, Scottish Government and the Northwest Regional Development Agency. This work was supported by the Aberdeen Biomedical Imaging Centre with financial support from the Roland Sutton Academic Trust (RSAT-0039/R/16) and the Saudi Cultural Bureau in contact with Jazan University (PhD scholarship for NAM). Data Availability: The datasets processed and analysed during the current study are available from the online open access UK Biobank repository (https://www.ukbiobank.ac.uk/). This research was conducted under the UK Biobank Resource under Application Number 24089 (PI Waiter).Peer reviewedPublisher PD

    Sex differences in the association of photoperiod with hippocampal subfield volumes in older adults : A crosssectional study in the UK Biobank cohort

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    Ā© 2020 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.Peer reviewedPublisher PD

    Neural changes related to motion processing in healthy aging

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    The authors wish to thank the research staff at the Aberdeen Biomedical Imaging Centre for their assistance during experimental setup and data collection, and James Urquhart for technical assistance. Funding: This work was supported by the Biotechnology and Biological Sciences Research Council [grant number BB/K007173/1].Peer reviewedPublisher PD

    Increased neural response to social rejection in major depression

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    Background: Being a part of community is critical for survival and individuals with major depressive disorder (MDD) have a greater sensitivity to interpersonal stress that makes them vulnerable to future episodes. Social rejection is a critical risk factor for depression and it is said to increase interpersonal stress and thereby impairing social functioning. It is therefore critical to understand the neural correlates of social rejection in MDD. Methods: To this end, we scanned 15 medicated MDD and 17 healthy individuals during a modified cyberball passing game, where participants were exposed to increasing levels of social exclusion. Neural responses to increasing social exclusion were investigated and compared between groups. Results: We showed that compared to controls, MDD individuals exhibited greater amygdala, insula, and ventrolateral prefrontal cortex activation to increasing social exclusion and this correlated negatively with hedonic tone and self-esteem scores across all participants. Conclusions: These preliminary results support the hypothesis that depression is associated with hyperactive response to social rejection. These findings highlight the importance of studying social interactions in depression, as they often lead to social withdrawal and isolation

    Validation and comparison of two automated methods to quantify brain white matter hyperintensities of presumed vascular origin

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    Funding Data collection was funded by grants from the Alzheimerā€™s Research Trust (now Alzheimerā€™s Research UK, grant reference: ART/SPG2003B), Alzheimerā€™s Research UK (grant reference: ARUK-SB2012B-2), the University of Aberdeen Development Trust (grant reference RGB3109) and NHS Grampian and the Chief Scientistā€™s Office (grant reference: CAF/08/08). JMJW is funded by the University of Aberdeen Development Trust and TauRx Therapeutics Ltd. CP is funded by Royal Surrey County Hospital NHS Foundation Trust. CJM, ADM, and GDW are funded by the Scottish Funding Council.Peer reviewedPublisher PD
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